Recent Publications

Cheatham, M. A. and P. Dallos, The dynamic range of inner hair cell and organ of Corti responses, J. Acoust. Soc. Amer. 107, 1508-1520 (2000).

Zheng, J., W. Shen, D.Z.Z. He, K. Long, L.D. Madison and P. Dallos, Prestin is the motor protein of cochlear outer hair cells, Nature 405, 149-155 (2000). With News and Views by M.C. Holley, ibid pp. 130-133 and News Focus by A. Cho in Science, 288: 1954-1955 (2000).

He, D.Z.Z. and P. Dallos, Properties of voltage-dependent somatic stiffness of cochlear outer hair cells, JARO 1, 64-81 (2000).

He, D.Z.Z., Zheng, J., Edge, R. and P. Dallos, Isolation of cochlear inner hair cells. Hearing Res 145: 156-160 (2000).

Richter, C.P., Edge, R., He, D.Z.Z. and P. Dallos, Development of the gerbil inner ear observed in the hemicochlea. JARO 1: 195-210 (2000).

Dallos, P. and D.Z.Z. He, Two models of outer hair cell stiffness and motility. JARO 1, 283-291 (2000).

Santos-Sacchi, J., Shen, W., Zheng, J. and P. Dallos, Effects of membrane potential and tension on prestin, the outer hair cell membrane protein, J. Physiol. (London) 531, 661-666 (2001). With Perspective by M.G. Evans and C.J. Kros, ibid p. 582 and Highlights in Nature Rev. Neurosci. 2: 313, (2001).

Sziklai I, Szönyi M. and P. Dallos, Phosphorylation mediates the influence of acetylcholine upon outer hair cell electromotility. Acta Otolaryngol.121: 153-156 (2001).

Oliver, D., D.Z.Z. He, N. Klöcker, J. Ludwig, U. Schulte, S. Waldegger, J.P. Ruppersberg, P. Dallos and B. Fakler, Intracellular anions as the voltage-sensor of prestin, the outer hair cell motor protein. Science 292: 2340-2343 (2001). With News and Views by R. Meech and M.C. Holley in Nature Neuroscience, 4: 771-773 (2001); also, Comments by R. Gagescu in Nature Reviews Molecular Cell Biology, 2: 565 (2001).

Zheng, J., K.B. Long, W. Shen, L.D. Madison and P. Dallos, Prestin topology: localization of protein epitopes in relation to the plasma membrane. NeuroReport 12: 1929-1935 (2001).

Cheatham, M.A. and P. Dallos, Inner hair cell response patterns: Implications for low-frequency hearing. J. Acoust. Soc. Amer. 110: 2034-2044 (2001).

Szönyi, M., D. Z.Z. He, O. Ribári, I. Sziklai and P. Dallos, Intracellular calcium concentration and outer hair cell electromotility, Brain Res. 922: 65-70 (2001).

He, D.Z.Z., J. Zheng and P. Dallos, Development of acetylcholine receptors in cultured outer hair cells, Hearing Res. 162: 113-125 (2001).

Dallos, P. and B. Fakler, Prestin, a new type of motor protein, Nature Rev. Mol. Cell. Biol. 3: 104-111 (2002).

Zheng, J., L.D. Madison, D. Oliver, B. Fakler and P. Dallos, Prestin, the motor protein of outer hair cells, Audiology and Neuro-Otology 7: 9-12 (2002).

Zheng, J., K.B. Long, D.Z.Z. He, J. Cheng, P. Dallos and L.D. Madison, Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cells using single cell-type specific suppressive hybridization. Audiology and Neuro-Otology 7: 277-288 (2002).

Zheng, J., K. B. Long, K. Matsuda, L. D. Madison, A. Ryan and P. Dallos, Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells, Mammalian Genome, 14: 87-96 (2003).

Liu, X.Z., X. M. Ouyang, X. J. Xia, J. Zheng, A. Pandya, F. Li , L. L. Du, K. O. Welch, C. Petit, R. J. H. Smith, B. T. Webb, D. Yan, K. S. Arnos , D. Corey, P. Dallos, W. E. Nance, Z. Y. Chen, Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss, Human Molecular Genetics 12: 1155-1162(2003).

He, D.Z.Z., S. Jia, P. Dallos, Prestin and the dynamic stiffness of cochlear outer hair cells. J. Neurosci. 23: 9089-9096 (2003).

Dallos, P., Organ of Corti kinematics. JARO 4: 416-421 (2003).

Emadi, G., C.-P. Richter, P. Dallos, Stiffness of the gerbil basilar membrane: radial and longitudinal variations. J. Neurophysiol. 91: 474-488 (2004).

Matsuda, K., J. Zheng, G.G. Du, N. Klöcker, L.D. Madison P. Dallos, N-linked glycosylation sites of the motor protein prestin: effects on electrophysiological function. J. Neurochem. 89: 928-938 (2004).

He, D.Z.Z., S. Jia, P. Dallos, Mechanoelectrical transduction of adult outer hair cells studied in the hemicochlea. Nature 429: 766-770 (2004).

Cheatham, M.A., K.H. Huynh, J. Gao, J. Zuo, P. Dallos, Cochlear function in Prestin knockout mice. J. Physiol. (London) 560.3: 821-830 (2004).

Deák, L. J. Zheng, S. Aguiñaga, A. Orem, G.G. Du, K. Matsuda, P. Dallos, Effects of cyclic nucleotides on prestin’s function. J. Physiol.(London) 563.2: 483-496 (2005).

Zheng, J., G.G. Du, A. Orem, S. Aguiñaga, L.D. Madison, P. Dallos, The carboxy terminus of prestin influences both motor function and plasma membrane targeting. J.Cell Science. 118: 2987-2996 (2005).

Cheatham, M.A. ,Zheng, J., Huynh, K.H. , Du, G.G., Gao, J., Zuo, J., Navarrete.E. and Dallos, P. Cochlear function in mice with only one copy of the Prestin gene. J. Physiol. (London) 569.1: 229-241 (2005).

Zheng, J., G.G. Du, C.T. Anderson, J.P. Keller, R. Edge, A. Orem, P. Dallos and M.A. Cheatham, Analysis of the oligomeric structure of the motor protein prestin. J. Biol. Chem. 281: 19916-19924 (2006).

Lu, T.K., S. Zhak, P. Dallos and R. Sarpeshkar, Negative feedback enables fast cochlear amplification with slow outer hair cells. Hear. Res. 214: 45-67 (2006)

Dallos, P., J. Zheng and M.A. Cheatham, Prestin and the cochlear amplifier. J. Physiol. (London) Invited, 576: 37-42 (2006).

Jia, S., P. Dallos, D.Z.Z. He, Mechanoelectric transduction of adult innner hair cells, J. Neurosci. 27: 1006-1014 (2007).

M.A. Cheatham, K. Huynh, J. Zheng, G.G. Du, R.M. Edge, C.T. Anderson, A.F. Ryan, J. Zuo and P. Dallos, Evaluation of a prestin mouse model derived from the 129S1 strain, Audiol. and Neurotol. 12: 379-390 (2007).

C.-P. Richter, G. Emadi , G. Getnick, A. Quesnel and P. Dallos, Tectorial membrane stiffness gradients, Biophys. J. 93: 2265-2276 (2007).

J. Gao, X. Wang, X. Wu, S. Aguinaga, K. Huynh, K. Matsuda, S. Jia, M. Patel, J. Zheng, M.A. Cheatham*, D.Z.Z. He*, P. Dallos* and J. Zuo*, Hyperpolarizing shifts of outer hair cell nonlinear capacitance and electromotility in prestin knockin mice do not change sensitivity or tuning, *Equal contributions. Proc. Natl. Acad. Sci. USA 104: 12542-12547 (2007).

P. Dallos, X. Wu, M.A. Cheatham, J. Gao, J. Zheng, C.T. Anderson, S. Jia, W.H.Y. Cheng, D.Z.Z. He and J. Zuo, Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 58: 333-339 (2008).