Charles R. Larson

Department of Communication Sciences and Disorders

Chuck Larson and his lab study the neural mechanisms controlling the voice and the larynx. They have found that when people hear their own voice through earphones, and when the voice pitch through the earphones is unexpectedly changed upwards or downwards, people automatically adjust the pitch of their voice. This phenomenon indicates that there is a close coupling between the auditory system's monitoring of voice and the motor system for adjusting the laryngeal system for voice output. Our recent research has focused on the brain mechanisms underlying the interaction between auditory feedback and voice control. We use EEG and fMRI techniques along with connectivity modeling to identify the timing and interactions between the various brain locations involved in these processes.

Lab Affiliation

Speech Physiology Laboratory

Education

PhD	Speech and Hearing Sciences, University of Washington
MA	Psychology, Arizona State University
BA	Psychology, The Colorado College

Publications

Russo, N. M., Larson, C., Kraus, N. Audio-Vocal System Regulation in Children with Autism Spectrum Disorders, Exp. Brain Res, 188, 111-2124, 2008.

Larson, C.R., Altman, K.W., Liu, H., Hain.  T.C. Interactions between auditory and somatosensory feedback for voice F0 control, Exp. Brain Res, 187, 613-621, 2008.

Liu, H., Xu, Y., Larson, C.R. Suppression of vocal responses to pitch perturbations during Mandarin speech, J.  Acoust. Soc. Am., 125, 2299-2306, 2009.

Behroozmand, R., Karvelis, L., Liu, H. and Larson, C. R. Vocalization-induced enhancement of the auditory cortex responsiveness during voice F0 feedback perturbation. Clinical Neurophysiology, Volume 120, Issue 7, July 2009, Pages 1303-1312.

Liu, H., Auger, J. and Larson, C.R. Voice fundamental frequency modulates vocal response to pitch perturbations during English speech. , J.  Acoust. Soc. Am. EL, 127 (1), 2010

Liu, H., Russo, N.M. and Larson, C.R. Age-related differences in vocal responses to pitch feedback perturbations: A preliminary study. J.  Acoust. Soc. Am., 127 (2), 1042-1046, 2010

Liu, H., Behroozmand, R., Larson, C.R. Enhanced neural responses to self-triggered voice pitch feedback perturbations. NeuroReport, 21 (7), 527 - 531, 2010.

Behroozmand, R., Liu, H., Larson, C.R. Time-dependent neural processing of auditory feedback during voice pitch error detection. J. Cog. Neurosci. 23 - 5,  1205-1217, 2011.

Peng Liu, Zhaocong Chen, Charles Larson, Dongfeng Huang, and Hanjun Liu. Auditory Feedback Control of Voice Fundamental Frequency in School Children. J. Acoust. Soc. Am. 128 (3), 1306-1312, 2010.

Liu, H., Wang, E.Q., Chen, Z., Liu, P., Larson, C.R., Huang, D. Effect of tonal native language on voice fundamental frequency responses to pitch feedback perturbations during sustained vocalizations. J. Acoust. Soc. Am. 128 (6), 3739-3746, 2010, PMCID: PMC3037774.

Liu, H., Meshman, M., Behroozmand, R. and Larson, C.R. Differential effects of perturbation direction and magnitude on the neural processing of voice pitch feedback. Clinical Neurophysiology,  122, 951-957, 2011.

Liu, H., Behroozmand, R., Bove, M. and Larson, C.R. Laryngeal electromyographic responses to perturbations in voice pitch auditory feedback. J. Acoust. Soc. Am. 129 (6), 3946-3954, 2011, PMCID: PMC3135150

Greenlee, J.W., Jackson, A.W., Chen, F., Larson. C.R., Oya, H., Hiroto, K., Chen, H., Howard, M.A. III. Human auditory cortical activation during self-vocalization. PLOS One, 6, (3), 1-15, 2011, PMID: 21390228

Behroozmand, R. and Larson, C.R. Error-dependent modulation of speech-induced auditory suppression for pitch-shifted voice feedback. BMC Neuroscience, 12:54, 2011.  PMCID 3120724

Behroozmand, R., Korzyukov, O. and Larson, C.R. Effects of harmonic complexity on ERP responses to pitch-shifted auditory feedback. Clinical Neurophysiology, (In Press).

Korzyukov, O., Karvelis, L., Behrozmand, R. and Larson, C.R. ERP correlates of auditory processing during automatic correction of unexpected perturbations in voice auditory feedback. Int. J. of Psychophysiology (In Press).

1998-2007 List of publications [pdf]

Recent Awards and Honors

2002	ASG Faculty Honor Roll
2005	ASG Honor Roll
2008	ASHA Zemlin Award

Recent Grants and Funding

2004-2009	NIH. Sensory Mechanisms of Voice Control, Direct Costs
2009-2014	NIH. Sensory Mechanisms of Voice Control, Direct Costs
2009-2011	NIH, ARRA award, Sensory Mechanisms of Voice Control
2009-2011	NIH, ARRA award, Sensory Mechanisms of Voice Control
2009-2014	NIH, Training Grant in Translational Research

Courses

CSD 112	Scientific Exploration of Communication
CSD 202	Biological Foundations of Human Communication
CSD 301	Anatomy and Physiology of the Vocal Mechanism
CSD 320	Physiologic Instrumentation
CSD 551	Topics in Communication Sciences and Disorders