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Mary Ann Cheatham

Department of Communication Sciences and Disorders

As part of the Auditory Physiology Laboratory, Mary Ann Cheatham has engaged in the study of cochlear nonlinearities and their origins. This investigation provides a foundation for further studies using the mouse in auditory research. Given that mice and humans carry several homologous genes for hereditary deafness, mice provide an important animal model for studying hearing loss of genetic origin, which affects at least 1 in 2000 births. In order to investigate the effect of targeted mutations on the development and maintenance of auditory function, procedures were devised for use with small animals. Because of the several mutagenesis programs now established worldwide, the numbers of genes associated with the inner ear will increase rapidly, thereby providing a genetic approach to the study of cochlear physiology.

Education

PhD	Audiology, Northwestern University
MA	Audiology, Northwestern University
BA	Speech Pathology and Audiology, University of Kansas

Publications

Cheatham, M.A., Zheng, J., Huynh, K.H., Du, G.G., Edge R.M., Anderson, C.T., Zuo, J., Ryan, A.F. and Dallos, P. (2007). Evaluation of an independent Prestin mouse model derived from the 129S1 strain. Audiol. Neurotol., in press.

Cheatham, M.A., Kuynh, K.H. and Dallos, P. (2006).  Nonlinear responses in prestin knockout mice:  Implications for cochlear function.  In:  A.L. Nuttall et al. (Eds), Auditory Mechanisms:  Processes and Models, World Scientific, New Jersey, pp. 218-225.

Cheatham, M.A., Zheng, J., Huynh, K.H., Du, G.G., Gao, J., Zuo, J., Navarrete, E. and Dallos, P. (2005).  Cochlear function in mice with only one copy of the Prestin gene.  J. Physiol., 569, 229-241.

Cheatham, M.A., Huynh, K.H., Gao, J., Zuo, J. and Dallos, P. (2004).  Cochlear function in Prestin knockout mice.  J. Physiol. 560, 821-830.